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Scriver et al. Page 127 Page 818 Page 759 Page 119 пппппппппппппппппппппппппппппппппппппппппChapter 9 Liposomal Drug Delivery Systems for Cancer Therapy 203 share trading canada 3 Desirable Ligand-Targeted Liposomal Therapeutics пComponent Considerations for optimum design пTarget antigen Targeting ligand Expression Highly and homogenously overexpressed in target tissue Function Vital to tumor progression, so that down-modulation does not occur or is associated with therapeutic benefit Shedding of antigen Limited, to avoid binding to soluble antigen and accelerated clearance Affinity High enough to ensure binding at low liposome concentrations Low enough to avoid вbinding-site barrierв effect (Weinstein) Immunogenicity Humanized MAb, to remove murine sequences.

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A major distinction between bacterial and eukaryotic genomes is th functional organization of structurally unrelated genes in bacterial operons.


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